Immunohistochemical Features of MMP-9 and pSTAT1 in Granuloma Annulare and Sarcoidosis: A Comparative Study of 62 Cases.

ABSTRACT:

Background

Granuloma annulare (GA) and sarcoidosis are granulomatous inflammatory diseases that share similarities.

Objective

To identify the histological and immunohistochemical (IHC) features of GA and sarcoidosis.

Methods

A retrospective review of 36 patients with GA and 26 with sarcoidosis was performed. Results from hematoxylin and eosin (H&E) staining and IHC staining of MMP-9 and pSTAT1 within the skin lesions of GA and sarcoidosis were analyzed, and random forest was applied for developing a predictive model.

Results

Significantly greater expressions of MMP-9 (especially in elastic fibers, EFs, P < 0.0001) and pSTAT1 (P = 0.0003) were observed in lesion samples of GA versus sarcoidosis patients. In GA patients, MMP-9 was significantly upre

SUBMITTER: Wu Z 

PROVIDER: S-EPMC10030222 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature