Establishing pteridine metabolism in a progressive isogenic breast cancer cell model - part II.

ABSTRACT:

Introduction

Determining the biological significance of pteridines in cancer development and progression remains an important step in understanding the altered levels of urinary pteridines seen in certain cancers. Our companion study revealed that several folate-derived pteridines and lumazines correlated with tumorigenicity in an isogenic, progressive breast cancer cell model, providing direct evidence for the tumorigenic origin of pteridines.

Objectives

This study sought to elucidate the pteridine biosynthetic pathway in a progressive breast cancer model via direct pteridine dosing to determine how pteridine metabolism changes with tumorigenicity.

Methods

First, MCF10AT breast cancer cells were dosed individually with 15 pteridines to determine which pteridines were

SUBMITTER: Rasmussen L 

PROVIDER: S-EPMC10030290 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature