Pooled analysis of epigenome-wide association studies of food consumption in KORA, TwinsUK and LLS.

ABSTRACT:

Purpose

Examining epigenetic patterns is a crucial step in identifying molecular changes of disease pathophysiology, with DNA methylation as the most accessible epigenetic measure. Diet is suggested to affect metabolism and health via epigenetic modifications. Thus, our aim was to explore the association between food consumption and DNA methylation.

Methods

Epigenome-wide association studies were conducted in three cohorts: KORA FF4, TwinsUK, and Leiden Longevity Study, and 37 dietary exposures were evaluated. Food group definition was harmonized across the three cohorts. DNA methylation was measured using Infinium MethylationEPIC BeadChip in KORA and Infinium HumanMethylation450 BeadChip in the Leiden study and the TwinsUK study. Overall, data from 2293 middle-aged men and

SUBMITTER: Hellbach F 

PROVIDER: S-EPMC10030421 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature