Allostatic load in opioid use disorder: a scoping review protocol.

ABSTRACT:

Introduction

Opioid use disorder affects 2.1 million individuals in the USA, causing more than 100 000 overdose-related deaths annually. While the neurobiological model of addiction is well described and accepted, there is a lack of morbidity and mortality prognosticators for patients struggling with opioid use disorder. Allostatic load index is a promising candidate for the basis of a prognostication tool. Previous studies show that allostatic load predicts both morbidity and mortality in a variety of cohorts. This scoping review protocol provides the rationale and steps for summarising and presenting existing evidence surrounding allostatic load in the context of opioid use disorder. Identification of current knowledge gaps will pave the way for subsequent prospective studies.

SUBMITTER: Fan JQ 

PROVIDER: S-EPMC10030489 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature