Network-level analysis of ageing and its relationship with diseases and tissue regeneration in the mouse liver.

ABSTRACT: The liver plays a vital role in maintaining whole-body metabolic homeostasis, compound detoxification and has the unique ability to regenerate itself post-injury. Ageing leads to functional impairment of the liver and predisposes the liver to non-alcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC). Mapping the molecular changes of the liver with ageing may help to understand the crosstalk of ageing with different liver diseases. A systems-level analysis of the ageing-induced liver changes and its crosstalk with liver-associated conditions is lacking. In the present study, we performed network-level analyses of the ageing liver using mouse transcriptomic data and a protein-protein interaction (PPI) network. A sample-wise analysis using network entropy measure was perfor

SUBMITTER: Porukala M 

PROVIDER: S-EPMC10030664 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature