Response to magnesium sulfate and adrenocorticotropic hormone combination therapy for infantile spasms with failed first-line treatments.

ABSTRACT:

Importance

Infantile spasm (IS) is a kind of refractory epilepsy. The first-line treatments for IS are adrenocorticotropic hormone (ACTH), oral corticosteroids, and vigabatrin.

Objective

This study aimed to evaluate the efficacy of magnesium sulfate and ACTH (MgSO₄+ACTH) combination therapy in patients with IS who failed first-line treatments.

Methods

In this retrospective study, the clinical data of patients with IS who failed first-line treatments were collected in the Chinese PLA General Hospital. Patients received MgSO₄+ACTH combination therapy after first-line treatments failed. The course of treatments was 2 weeks. The therapeutic dose of ACTH and MgSO₄ was 2.5 U·kg^-1·d^-1 and 0.25 g·kg^-1·d^-1<

SUBMITTER: Wang Q 

PROVIDER: S-EPMC10030695 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature