Identification of mitochondria-related key gene and association with immune cells infiltration in intervertebral disc degeneration.

ABSTRACT: Intervertebral disc (IVD) degeneration and its inflammatory microenvironment can result in discogenic pain, which has been shown to stem from the nucleus pulposus (NP). Increasing evidence suggests that mitochondrial related genes are strictly connected to cell functionality and, importantly, it can regulate cell immune activity in response to damaged associated signals. Therefore, identification of mitochondria related genes might offer new diagnostic markers and therapeutic targets for IVD degeneration. In this study, we identified key genes involved in NP tissue immune cell infiltration during IVD degeneration by bioinformatic analysis. The key modules were screened by weighted gene co-expression network analysis (WCGNA). Characteristic genes were identified by random forest analysis. T

SUBMITTER: Guo W 

PROVIDER: S-EPMC10030706 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature