Remodeling of the gut microbiome by Lactobacillus johnsonii alleviates the development of acute myocardial infarction.

ABSTRACT:

Introduction

The gut microbial community, which can be disturbed or repaired by changes in the internal environment, contributes to the development of acute myocardial infarction (AMI). Gut probiotics play a role in microbiome remodeling and nutritional intervention post-AMI. A newly isolated Lactobacillus johnsonii strain EU03 has shown potential as a probiotic. Here, we investigated the cardioprotective function and mechanism of L. johnsonii through gut microbiome remodeling in AMI rats.

Methods

A rat model of left anterior descending coronary artery ligation (LAD)-mediated AMI was assessed with echocardiography, histology, and serum cardiac biomarkers to evaluate the beneficial effects of L. johnsonii. The immunofluorescence analysis was utilized to v

SUBMITTER: Zhong X 

PROVIDER: S-EPMC10030800 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature