Chlorin e6-associated photodynamic therapy enhances abscopal antitumor effects via inhibition of PD-1/PD-L1 immune checkpoint.

ABSTRACT: We hypothesized that photodynamic therapy (PDT) with Chlorin e6 (Ce6) enhances antitumor abscopal effects via inhibition of the programmed cell death-1/programmed death-ligand 1 (PD-1/PD-L1) immune checkpoint. By using syngeneic melanoma and pancreatic tumor mouse models, we studied the Ce6-PDT-induced immune responses in local and distant tumor microenvironments. In addition, the Ce6-PDT's target in the PD-1/PD-L1 interaction was analyzed in MC38-hPD-L1 colon cancer and PD-1 expressing Jurkat T cell coculture. The tumors in the irradiated and non-irradiated sites in the abscopal effective (Abs_eff) group of both mouse models were regressed, proving the abscopal effect. The immunogenic effect in the Abs_eff group was associated with an expansion of T cell and other immu

SUBMITTER: Gurung P 

PROVIDER: S-EPMC10030802 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature