Microbial composition of tumorous and adjacent gastric tissue is associated with prognosis of gastric cancer.

ABSTRACT: Helicobacter pylori (H. pylori) infection has been considered as the main causal factor in gastric carcinogenesis, but other bacterial species may also play an important role in pathophysiology of gastric cancer. The aim of the study was to explore the link between gastric cancer prognosis and the mucosal microbial community in tumorous and adjacent gastric tissue. The bacterial profile was analysed using 16S sequencing (V1-V2 region). Microbial differences were mostly characterized by lower relative abundances of H. pylori in tumorous gastric tissues. Bacterial community and outcome data analysis revealed the genus Fusobacterium and Prevotella significantly associated with worse overall survival in gastric cancer patients. In particular, Fusobacterium was associated with significant incre

SUBMITTER: Lehr K 

PROVIDER: S-EPMC10030820 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature