Characterization of the Staphylococcus xylosus methylome reveals a new variant of type I restriction modification system in staphylococci.

ABSTRACT: Restriction modification (RM) systems are known to provide a strong barrier to the exchange of DNA between and within bacterial species. Likewise, DNA methylation is known to have an important function in bacterial epigenetics regulating essential pathways such as DNA replication and the phase variable expression of prokaryotic phenotypes. To date, research on staphylococcal DNA methylation focused mainly on the two species Staphylococcus aureus and S. epidermidis. Less is known about other members of the genus such as S. xylosus, a coagulase-negative commensal of mammalian skin. The species is commonly used as starter organism in food fermentations but is also increasingly considered to have an as yet elusive function in bovine mastitis infections. We analyzed the met

SUBMITTER: Schiffer CJ 

PROVIDER: S-EPMC10030836 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature