The Superfund Research Program Analytics Portal: linking environmental chemical exposure to biological phenotypes.

ABSTRACT: The OSU/PNNL Superfund Research Program (SRP) represents a longstanding collaboration to quantify Polycyclic Aromatic Hydrocarbons (PAHs) at various superfund sites in the Pacific Northwest and assess their potential impact on human health. To link the chemical measurements to biological activity, we describe the use of the zebrafish as a high-throughput developmental toxicity model that provides quantitative measurements of the exposure to chemicals. Toward this end, we have linked over 150 PAHs found at Superfund sites to the effect of these same chemicals in zebrafish, creating a rich dataset that links environmental exposure to biological response. To quantify this response, we have implemented a dose-response modelling pipeline to calculate benchmark dose parameters which enable poten

SUBMITTER: Gosline SJC 

PROVIDER: S-EPMC10030892 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature