Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care (HYBRID II): a multi-centre, randomised, double-blind, placebo-controlled trial.

ABSTRACT:

Background

Inhaled molecular hydrogen gas (H₂) has been shown to improve outcomes in animal models of cardiac arrest (CA). H₂ inhalation is safe and feasible in patients after CA. We investigated whether inhaled H₂ would improve outcomes after out-of-hospital CA (OHCA).

Methods

HYBRID II is a prospective, multicentre, randomised, double-blind, placebo-controlled trial performed at 15 hospitals in Japan, between February 1, 2017, and September 30, 2021. Patients aged 20-80 years with coma following cardiogenic OHCA were randomly assigned (1:1) using blinded gas cylinders to receive supplementary oxygen with 2% H₂ or oxygen (control) for 18 h. The primary outcome was the proportion of patients with a 90-day Cerebral Performance Categ

SUBMITTER: Tamura T 

PROVIDER: S-EPMC10030910 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature