Causal relationship between thyroid dysfunction and hallux valgus: A two-sample Mendelian randomization study.

ABSTRACT:

Introduction

Previous observational studies have reported that thyroid dysfunction is associated with hallux valgus (HV). However, the causal effect of thyroid dysfunction on hallux valgus is still unknown. To assess whether there is a causal relationship between thyroid dysfunction and hallux valgus, we performed a two-sample Mendelian randomization (MR) study.

Methods

The data of the two-sample Mendelian randomization study were obtained from public databases. In this study, hypothyroidism, hyperthyroidism, free thyroxine (FT4), and thyrotropin (TSH) were chosen as exposures. The single nucleotide polymorphisms (SNP) of hypothyroidism and hyperthyroidism were from the genome-wide association studies (GWAS) of the IEU database, including 337,159 subjects. Data for FT4 and T

SUBMITTER: Xiong B 

PROVIDER: S-EPMC10030973 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature