Understanding the dosing-time-dependent antihypertensive effect of valsartan and aspirin through mathematical modeling.

ABSTRACT: Chronopharmacology of arterial hypertension impacts the long-term cardiovascular risk of hypertensive subjects. Therefore, clinical and computational studies have proposed optimizing antihypertensive medications' dosing time (Ta). However, the causes and mechanisms underlying the Ta-dependency antihypertensive effect have not been elucidated. Here we propose using a Ta- dependent effect model to understand and predict the antihypertensive effect of valsartan and aspirin throughout the day in subjects with grade I or II essential hypertension. The model based on physiological regulation mechanisms includes a periodic function for each parameter that changes significantly after treatment. Circadian variations of parameters depending on the dosing time allowed the determination of regulation

SUBMITTER: Cortes-Rios J 

PROVIDER: S-EPMC10031009 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature