Long-term systemic and mucosal SARS-CoV-2 IgA response and its association with persistent smell and taste disorders.

ABSTRACT:

Introduction

Current approved COVID-19 vaccines, notably mRNA and adenoviral vectored technologies, still fail to fully protect against infection and transmission of various SARS-CoV-2 variants. The mucosal immunity at the upper respiratory tract represents the first line of defense against respiratory viruses such as SARS-CoV-2 and is thus critical to develop vaccine blocking human-to-human transmission.

Methods

We measured systemic and mucosal Immunoglobulin A (IgA) response in serum and saliva from 133 healthcare workers from Percy teaching military hospital following a mild infection (SARS-CoV-2 Wuhan strain, n=58) or not infected (n=75), and after SARS-CoV-2 vaccination (Vaxzevria®/Astrazeneca and/or Comirnaty®/Pfizer).

Results

While serum anti-SARS-CoV-2 Spike I

SUBMITTER: Denis J 

PROVIDER: S-EPMC10031022 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature