A novel risk score model based on gamma-aminobutyric acid signature predicts the survival prognosis of patients with breast cancer.

ABSTRACT:

Background

Gamma-aminobutyric acid (GABA) participates in the migration, differentiation, and proliferation of tumor cells. However, the GABA-related risk signature has never been investigated. Hence, we aimed to develop a reliable gene signature based on GABA pathways-related genes (GRGs) to predict the survival prognosis of breast cancer patients.

Methods

GABA-related gene sets were acquired from the MSigDB database, while mRNA gene expression profiles and corresponding clinical data of breast cancer patients were downloaded from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases. Univariate Cox regression analysis was used to identify prognostic-associated GRGs. Subsequently, LASSO analysis was applied to establish a risk score model. We also c

SUBMITTER: Yang L 

PROVIDER: S-EPMC10031029 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature