A bi-directional Mendelian randomization study of sarcopenia-related traits and type 2 diabetes mellitus.

ABSTRACT:

Background

Previous studies have reported an association between sarcopenia and type 2 diabetes mellitus (T2DM), but causation was prone to confounding factors. A more robust research approach is urgently required to investigate the causal relationship between sarcopenia and T2DM.

Methods

The bi-directional two-sample MR study was carried out in two stages: Sarcopenia-related traits were investigated as exposure while T2DM was investigated as an outcome in the first step, whereas the second step was reversed. The GWAS summary data for hand-grip strength (n = 256,523), appendicular lean mass (ALM, n = 450,243), and walking pace (n = 459,915) were obtained from the UK Biobank. T2DM data were obtained from one of the biggest case-control studies on diabetes (DIAGRAM; n = 180,83

SUBMITTER: Chen S 

PROVIDER: S-EPMC10031051 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature