Myricetin attenuates hypoxic-ischemic brain damage in neonatal rats via NRF2 signaling pathway.

ABSTRACT: Introduction: Hypoxic-ischemic encephalopathy (HIE) is a crucial cause of neonatal death and neurological sequelae, but currently there is no effective therapy drug for HIE. Both oxidative stress and apoptosis play critical roles in the pathological development of HIE. Myricetin, a naturally extracted flavonol compound, exerts remarkable effects against oxidative stress, apoptosis, and inflammation. However, the role and underlying molecular mechanism of myricetin on HIE remain unclear. Methods: In this study, we established the neonatal rats hypoxic-ischemic (HI) brain damage model in vivo and CoCl₂ induced PC1₂ cell model in vitro to explore the neuroprotective effects of myricetin on HI injury, and illuminate the potential mechanism.

SUBMITTER: Chen T 

PROVIDER: S-EPMC10031108 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature