Temporal dynamics of TNF-mediated changes in hematopoietic stem cell function and recovery.

ABSTRACT: While tumor necrosis factor (TNF) is a critical mediator of appropriate immune response and tissue repair, its misregulation is linked to cancer, autoimmunity, bone marrow failure, and aging. Understanding the context-dependent roles of TNF is essential for elucidating normal and pathogenic conditions and to guide clinical therapy advancements. Prior studies suggested that TNF restricts the self-renewal capacity of hematopoietic stem cells (HSCs), but its long-term effect on HSCs remains unclear. Here, we demonstrate that in vivo TNF administration results in a transient exit of HSCs from quiescence, which coincides with a compromised repopulation capacity. These functional changes are; however, fully reversible even following prolonged/chronic transient exposure to TNF. Notably, an

SUBMITTER: Rundberg Nilsson A 

PROVIDER: S-EPMC10031135 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature