TRPV4 functional status in cystic cells regulates cystogenesis in autosomal recessive polycystic kidney disease during variations in dietary potassium.

ABSTRACT: Mechanosensitive TRPV4 channel plays a dominant role in maintaining [Ca²⁺ ]_i homeostasis and flow-sensitive [Ca²⁺ ]_i signaling in the renal tubule. Polycystic kidney disease (PKD) manifests as progressive cyst growth due to cAMP-dependent fluid secretion along with deficient mechanosensitivity and impaired TRPV4 activity. Here, we tested how regulation of renal TRPV4 function by dietary K⁺ intake modulates the rate of cystogenesis and mechanosensitive [Ca²⁺ ]_i signaling in cystic cells of PCK453 rats, a homologous model of human autosomal recessive PKD (ARPKD). One month treatment with both high KCl (5% K⁺ ) and KB/C (5% K⁺ with bicarbonate/citrate) diets significantly increased TRPV4 levels

SUBMITTER: Pyrshev K 

PROVIDER: S-EPMC10031299 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature