Ontology highlight
ABSTRACT:
SUBMITTER: Peng H
PROVIDER: S-EPMC10031304 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
Peng Huan H Lin Yunqing Y Hu Fangxiao F Lv Cui C Wu Bingyan B Weng Qitong Q Liu Lijuan L Xia Chengxiang C Liu Xiaofei X Zhao Yalan Y Zhang Qi Q Geng Yang Y Zhang Mengyun M Wang Jinyong J
Stem cell reports 20230216 3
Regenerating prolonged multi-lineage hematopoiesis from pluripotent stem cells (PSCs), an unlimited cell source, is a crucial aim of regenerative hematology. In this study, we used a gene-edited PSC line and revealed that simultaneous expression of three transcription factors, Runx1, Hoxa9, and Hoxa10, drove the robust emergence of induced hematopoietic progenitor cells (iHPCs). The iHPCs engrafted successfully in wild-type animals and repopulated abundant and complete myeloid-, B-, and T-lineag ...[more]