Quality of life in children and adolescents with hemophilia A: A systematic review and meta-analysis.

ABSTRACT:

Background

Various instruments have been used to assess health-related quality of life (HRQoL) in children and adolescents with hemophilia A.

Objective

We systematically reviewed the literature to summarize HRQoL measurement instruments and outcomes in this population.

Methods

MEDLINE, Embase, Cochrane CENTRAL, and LILACS databases were searched. Studies published from 2010 to 2021, reporting HRQoL assessed by generic or hemophilia-specific instruments in individuals aged 0 to 18 years were included. Two independent reviewers performed screening, selection, and data abstraction. Data were meta-analyzed using the generic inverse variance method with the random-effects model for single-arm studies reporting instrument-specific mean total HRQoL scores. Prespecified subgr

SUBMITTER: Azeredo-da-Silva AF 

PROVIDER: S-EPMC10031335 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature