Associations of hemolysis and anemia with cardiopulmonary dysfunction in an adult sickle cell disease cohort.

ABSTRACT:

Background

Hemolysis contributes to the anemia of sickle cell disease (SCD). Hemolysis and anemia are distinct but inter-related pathophysiological processes that underlie end-organ dysfunction in this condition. We hypothesized that real-world medical tests would reveal distinct contributions of hemolysis and anemia to certain cardiopulmonary changes in adults with SCD.

Methods

We assessed laboratory and clinical tests of cardiopulmonary function obtained during routine delivery of care in 442 adult SCD patients. We characterized hemolysis by the first principal component (PC1) of reticulocyte percent, lactate dehydrogenase (LDH), aspartate amino transferase (AST) and total bilirubin- the hemolytic component. The relationships of hemoglobin concentration and hemolysis to or

SUBMITTER: Njoku F 

PROVIDER: S-EPMC10031509 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature