Dataset Information

Autoimmune disease and risk of postpartum venous thromboembolism.

ABSTRACT:

Background

The risk of pregnancy-related mortality in the United States has nearly doubled since 1990, with venous thromboembolism (VTE) accounting for approximately 10% of these deaths.

Objectives

The objective of this study was to assess whether preexisting autoimmune disease is a risk factor for postpartum VTE.

Methods

Using the MarketScan Commercial and Medicare Supplemental administrative databases, a retrospective cohort study analyzed whether postpartum persons with autoimmune disease had a higher risk of postpartum VTE incidence than postpartum persons without autoimmune disease. Using International Classification of Diseases codes, we identified 757,303 individuals of childbearing age who had a valid delivery date with at least 12 weeks of follow-up.

Results

Individuals were, on average, 30.7 years old (SD, 5.4), and 3.7% (N = 27,997 of 757,303) of them had evidence of preexisting autoimmune disease. In covariate-adjusted models, postpartum persons with preexisting autoimmune disease had higher rates of postpartum VTE than postpartum persons without autoimmune disease (hazard ratio [HR], 1.33; 95% CI, 1.07-1.64). When analyzed by individual autoimmune disease, those with systemic lupus erythematosus (HR, 2.49; 95% CI, 1.47-4.21) and Crohn's disease (HR, 2.49; 95% CI, 1.34-4.64) were at an elevated risk of postpartum VTE compared with those without autoimmune disease.

Conclusion

Autoimmune disease was associated with a higher rate of postpartum VTE, with evidence that the association was most pronounced among individuals with systemic lupus erythematosus and Crohn's disease. These findings suggest that postpartum persons of childbearing age with autoimmune disease may require more monitoring and prophylactic care after delivery to prevent potentially fatal VTE events.

SUBMITTER: Walker RF

PROVIDER: S-EPMC10031534 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Publications

Autoimmune disease and risk of postpartum venous thromboembolism.

Walker Rob F RF Zakai Neil A NA Mason Susan M SM MacLehose Richard F RF Norby Faye L FL Evensen Line H LH Alonso Alvaro A Lutsey Pamela L PL

Research and practice in thrombosis and haemostasis 20230223 2

<h4>Background</h4>The risk of pregnancy-related mortality in the United States has nearly doubled since 1990, with venous thromboembolism (VTE) accounting for approximately 10% of these deaths.<h4>Objectives</h4>The objective of this study was to assess whether preexisting autoimmune disease is a risk factor for postpartum VTE.<h4>Methods</h4>Using the MarketScan Commercial and Medicare Supplemental administrative databases, a retrospective cohort study analyzed whether postpartum persons with ...[more]

PMID: 36970127

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Dataset Information

Autoimmune disease and risk of postpartum venous thromboembolism.

Background

Objectives

Methods

Results

Conclusion

Publications

Autoimmune disease and risk of postpartum venous thromboembolism.

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