CD80 DNA methylation and single-nucleotide polymorphism associated with clopidogrel response: a whole-genome DNA methylation analysis in acute coronary syndrome.

ABSTRACT:

Background

Dual antiplatelet therapy with clopidogrel and aspirin is the primary treatment for patients who undergo percutaneous coronary intervention. However, the interindividual difference in clopidogrel response is remarkable, and high on-treatment platelet reactivity (HTPR) can increase the risk of thrombotic events after percutaneous coronary intervention.

Objective

We studied novel accessible factors that possibly affect clopidogrel response in DNA methylation.

Methods

Methylation 850K bead chips were used to detect DNA methylation levels. The platelet reactivity index (PRI) was determined in 330 subjects with acute coronary syndrome (ACS) after administration of clopidogrel 300 mg loading dose or at least 5 days of 75 mg daily maintenance dose.

Results

SUBMITTER: Song PY 

PROVIDER: S-EPMC10031538 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature