Hybrid techniques for myocardial regeneration: state of the art and future perspectives.

ABSTRACT: Myocardium has a limited proliferative capacity, and adult hearts are considered incapable of regenerating after injury. A significant loss in the viable myocardium eventually diminishes the heart's ability to contract synchronously, leading to heart failure. Despite the development in interventional and pharmacological treatment for ischemic heart disease and heart failure, there is a significant number of highly symptomatic patients. For these individuals, treatments that stimulate myocardial regeneration can offer alleviation of dyspnea and angina and improvement in quality of life. Stem cells are known to promote neovascularization and endothelial repair. Various stem cell lines have been investigated over the years to establish those with the highest potential to differentiate into ca

SUBMITTER: Kedziora A 

PROVIDER: S-EPMC10031663 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature