CAS Array: design and assessment of a genotyping array for Chinese biobanking.

ABSTRACT:

Background

Chronic diseases are becoming a critical challenge to the aging Chinese population. Biobanks with extensive genomic and environmental data offer opportunities to elucidate the complex gene-environment interactions underlying their aetiology. Genome-wide genotyping array remains an efficient approach for large-scale genomic data collection. However, most commercial arrays have reduced performance for biobanking in the Chinese population.

Materials and methods

Deep whole-genome sequencing data from 2 641 Chinese individuals were used as a reference to develop the CAS array, a custom-designed genotyping array for precision medicine. Evaluation of the array was performed by comparing data from 384 individuals assayed both by the array and whole-genome sequencing. Vali

SUBMITTER: Tian Z 

PROVIDER: S-EPMC10031742 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature