Neural Correlates of Formal Thought Disorder Dimensions in Psychosis.

ABSTRACT:

Background and hypothesis

Formal thought disorder (FTD) is a core symptom of psychosis, but its neural correlates remain poorly understood. This study tested whether four FTD dimensions differ in their association with brain perfusion and brain structure.

Study design

This cross-sectional study investigated 110 patients with schizophrenia spectrum disorders using 3T magnetic resonance imaging (MRI). The Thought and Language Disorder scale (TALD) was utilized, which comprises four subscales: Objective Positive (OP), Objective Negative (ON), Subjective Positive (SP), and Subjective Negative (SN). Resting-state cerebral blood flow (rsCBF), cortical thickness (CortTh), gray matter volume (GMV), and diffusion MRI tractography were tested for associations with TALD subscales contr

SUBMITTER: Maderthaner L 

PROVIDER: S-EPMC10031743 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature