Influence of verapamil on pressure overload-induced ventricular arrhythmias by regulating gene-expression profiles.

ABSTRACT:

Background

Life-threatening ventricular arrhythmias can lead to sudden cardiac death in patients. This study aimed to investigate the changes in gene profiles involved when verapamil (VRP) affects increased wall stress (pressure overload)-induced ventricular arrhythmias, thus revealing the potential causative molecular mechanisms and therapeutic targets through gene-expression identification and functional analysis.

Methods

Animal models with wall stress-induced ventricular arrhythmias were established. Low (0.5 mg/kg) and high (1 mg/kg) doses of VRP were administered intravenously 10 minutes before transverse aortic constriction, and average ventricular arrhythmia scores were calculated. Next, we evaluated the molecular role of VRP by characterising differential gene-expres

SUBMITTER: Cheng X 

PROVIDER: S-EPMC10031859 | biostudies-literature | 2022 Nov-Dec 23

REPOSITORIES: biostudies-literature