Evidence for the role of transcription factors in the co-transcriptional regulation of intron retention.

ABSTRACT:

Background

Alternative splicing is a widespread regulatory phenomenon that enables a single gene to produce multiple transcripts. Among the different types of alternative splicing, intron retention is one of the least explored despite its high prevalence in both plants and animals. The recent discovery that the majority of splicing is co-transcriptional has led to the finding that chromatin state affects alternative splicing. Therefore, it is plausible that transcription factors can regulate splicing outcomes.

Results

We provide evidence for the hypothesis that transcription factors are involved in the regulation of intron retention by studying regions of open chromatin in retained and excised introns. Using deep learning models designed to distinguish between regions of ope

SUBMITTER: Ullah F 

PROVIDER: S-EPMC10031921 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature