Persistence of parental age effect on somatic mutation rates across generations in Arabidopsis.

ABSTRACT: In the model plant Arabidopsis thaliana, parental age is known to affect somatic mutation rates in their immediate progeny and here we show that this age dependent effect persists across successive generations. Using a set of detector lines carrying the mutated uidA gene, we examined if a particular parental age maintained across five consecutive generations affected the rates of base substitution (BSR), intrachromosomal recombination (ICR), frameshift mutation (FS), and transposition. The frequency of functional GUS reversions were assessed in seedlings as a function of identical/different parental ages across generations. In the context of a fixed parental age, BSR/ICR rates were unaffected in the first three generations, then dropped significantly in the 4th and increased in most instan

SUBMITTER: Bhushan S 

PROVIDER: S-EPMC10031922 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature