The role of SIRT1 level and SIRT1 gene polymorphisms in optic neuritis patients with multiple sclerosis.

ABSTRACT:

The aim

To investigate the role of Sirtuin 1 (SIRT1) level and SIRT1 (rs3818292, rs3758391, rs7895833) gene polymorphisms in patients with optic neuritis (ON) and multiple sclerosis (MS).

Methods

79 patients with ON and 225 healthy subjects were included in the study. ON patients were divided into 2 subgroups: patients with MS (n = 30) and patients without MS (n = 43). 6 ON patients did not have sufficient data for MS diagnosis and were excluded from the subgroup analysis. DNA was extracted from peripheral blood leukocytes and genotyped by real-time polymerase chain reaction. Results were analysed using the program "IBM SPSS Statistics 27.0".

Results

We discovered that SIRT1 rs3758391 was associated with a twofold increased odds of developing ON under the codominant (

SUBMITTER: Kubiliute A 

PROVIDER: S-EPMC10031967 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature