Obese asthma phenotypes display distinct plasma biomarker profiles.

ABSTRACT:

Background

Obese asthma is a complex phenotype and further characterization of the pathophysiology is needed. This study aimed to explore inflammation-related plasma biomarkers in lean and overweight/obese asthmatics.

Methods

We elucidated levels of inflammation-related plasma proteins in obese asthma phenotypes in the population-based cohort BAMSE (Swedish: Children, Allergy, Milieu, Stockholm, Epidemiology) using data from 2069 24-26-year-olds. Subjects were divided into lean asthma (n = 166), lean controls (n = 1440), overweight/obese asthma (n = 73) and overweight/obese controls (n = 390). Protein levels (n = 92) were analysed using the Olink Proseek Multiplex Inflammation panel.

Results

Of the 92 included proteins, 41 were associated with lean and/or overweight/o

SUBMITTER: Bjorkander S 

PROVIDER: S-EPMC10032201 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature