Outcome and clinical features in juvenile myasthenia gravis: A systematic review and meta-analysis.

ABSTRACT:

Background

Juvenile myasthenia gravis (JMG) is a rare autoimmune disease that has so far only been described in small cohort studies. We defined the clinical characteristics, management, and outcomes of JMG patients over the past 22 years.

Methods

A search of PubMed, EMBASE, and web of science (1/2000-2/2022) identified all English language and human studies of JMG. The population was patients diagnosed with JMG. Outcomes included the history of myasthenic crisis, autoimmune comorbidity, mortality, and treatment outcome. Data extraction was performed by independent reviewers. And we performed a pooled reanalysis of all published data in the included studies and compared with other studies of adult cohorts.

Results

We identified 11 articles describing 1,109 patients di

SUBMITTER: Lin Y 

PROVIDER: S-EPMC10032342 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature