Quantification of Behavioral Deficits in Developing Mice With Dystonic Behaviors.

ABSTRACT: Converging evidence from structural imaging studies in patients, the function of dystonia-causing genes, and the comorbidity of neuronal and behavioral defects all suggest that pediatric-onset dystonia is a neurodevelopmental disorder. However, to fully appreciate the contribution of altered development to dystonia, a mechanistic understanding of how networks become dysfunctional is required for early-onset dystonia. One current hurdle is that many dystonia animal models are ideally suited for studying adult phenotypes, as the neurodevelopmental features can be subtle or are complicated by broad developmental deficits. Furthermore, most assays that are used to measure dystonia are not suited for developing postnatal mice. Here, we characterize the early-onset dystonia in Ptf1a

SUBMITTER: Van Der Heijden ME 

PROVIDER: S-EPMC10032351 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature