Water exchange rates measure active transport and homeostasis in neural tissue.

ABSTRACT: For its size, the brain is the most metabolically active organ in the body. Most of its energy demand is used to maintain stable homeostatic physiological conditions. Altered homeostasis and active states are hallmarks of many diseases and disorders. Yet there is currently no direct and reliable method to assess homeostasis and absolute basal activity of cells in the tissue noninvasively without exogenous tracers or contrast agents. We propose a novel low-field, high-gradient diffusion exchange nuclear magnetic resonance (NMR) method capable of directly measuring cellular metabolic activity via the rate constant for water exchange across cell membranes. Exchange rates are 140±16 s -1 under normal conditions in viable ex vivo neonatal mouse spinal cords. High repeatability across samples su

SUBMITTER: Williamson NH 

PROVIDER: S-EPMC10032361 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature