Pneumolysin as a target for new therapies against pneumococcal infections: A systematic review.

ABSTRACT:

Background

This systematic review evaluates pneumolysin (PLY) as a target for new treatments against pneumococcal infections. Pneumolysin is one of the main virulence factors produced by all types of pneumococci. This toxin (53 kDa) is a highly conserved protein that binds to cholesterol in eukaryotic cells, forming pores that lead to cell destruction.

Methods

The databases consulted were MEDLINE, Web of Science, and Scopus. Articles were independently screened by title, abstract, and full text by two researchers, and using consensus to resolve any disagreements that occurred. Articles in other languages different from English, patents, cases report, notes, chapter books and reviews were excluded. Searches were restricted to the years 2000 to 2021. Methodological quality was

SUBMITTER: Cima Cabal MD 

PROVIDER: S-EPMC10032530 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature