Evolution of highly pathogenic H5N1 influenza A virus in the central nervous system of ferrets.

ABSTRACT: Central nervous system (CNS) disease is the most common extra-respiratory tract complication of influenza A virus infections in humans. Remarkably, zoonotic highly pathogenic avian influenza (HPAI) H5N1 virus infections are more often associated with CNS disease than infections with seasonal influenza viruses. Evolution of avian influenza viruses has been extensively studied in the context of respiratory infections, but evolutionary processes in CNS infections remain poorly understood. We have previously observed that the ability of HPAI A/Indonesia/5/2005 (H5N1) virus to replicate in and spread throughout the CNS varies widely between individual ferrets. Based on these observations, we sought to understand the impact of entrance into and replication within the CNS on the evolutionary dyna

SUBMITTER: Siegers JY 

PROVIDER: S-EPMC10032531 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature