Microstructural and neurochemical plasticity mechanisms interact to enhance human perceptual decision-making.

ABSTRACT: Experience and training are known to boost our skills and mold the brain's organization and function. Yet, structural plasticity and functional neurotransmission are typically studied at different scales (large-scale networks, local circuits), limiting our understanding of the adaptive interactions that support learning of complex cognitive skills in the adult brain. Here, we employ multimodal brain imaging to investigate the link between microstructural (myelination) and neurochemical (GABAergic) plasticity for decision-making. We test (in males, due to potential confounding menstrual cycle effects on GABA measurements in females) for changes in MRI-measured myelin, GABA, and functional connectivity before versus after training on a perceptual decision task that involves identifying targe

SUBMITTER: Ziminski JJ 

PROVIDER: S-EPMC10032544 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature