Cohort Study and Bias Analysis of the Obesity Paradox Across Stages of Chronic Kidney Disease.

ABSTRACT:

Objective

In advanced chronic kidney disease (CKD), patients with obesity often have better outcomes than patients without obesity, often called the 'obesity paradox'. Yet, in CKD, the prevalence of inflammation increases as CKD progresses. Although a potential confounder, inflammation may be left unaccounted in obesity-mortality studies. We examined the associations of body mass index (BMI) with all-cause and cause-specific mortality across CKD stages, with consideration for uncontrolled confounding due to unmeasured inflammation.

Methods

We investigated 2,703,512 patients with BMI data between 2004 and 2006. We used Cox models to examine the associations of BMI with all-cause, cardiovascular, and cancer mortality, (ref: BMI 25-<30 kg/m²), adjusted for clinical c

SUBMITTER: Soohoo M 

PROVIDER: S-EPMC10032545 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature