Inhibition of peptidoglycan synthesis is sufficient for total arrest of staphylococcal cell division.

ABSTRACT: Bacterial cell wall biosynthesis is the target of many important antibiotics. Its spatiotemporal organization is closely coordinated with cell division. However, the role of peptidoglycan synthesis within cell division is not fully understood. Even less is known about the impact of antibiotics on the coordination of these two essential processes. Visualizing the essential cell division protein FtsZ and other key proteins in Staphylococcus aureus, we show that antibiotics targeting peptidoglycan synthesis arrest cell division within minutes of treatment. The glycopeptides vancomycin and telavancin completely inhibit septum constriction in all phases of cell division. The beta-lactam oxacillin stops division progress by preventing recruitment of the major peptidoglycan synthase PBP2 t

SUBMITTER: Puls JS 

PROVIDER: S-EPMC10032595 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature