Functional neurological restoration of amputated peripheral nerve using biohybrid regenerative bioelectronics.

ABSTRACT: The development of neural interfaces with superior biocompatibility and improved tissue integration is vital for treating and restoring neurological functions in the nervous system. A critical factor is to increase the resolution for mapping neuronal inputs onto implants. For this purpose, we have developed a new category of neural interface comprising induced pluripotent stem cell (iPSC)-derived myocytes as biological targets for peripheral nerve inputs that are grafted onto a flexible electrode arrays. We show long-term survival and functional integration of a biohybrid device carrying human iPSC-derived cells with the forearm nerve bundle of freely moving rats, following 4 weeks of implantation. By improving the tissue-electronics interface with an intermediate cell layer, we have demon

SUBMITTER: Rochford AE 

PROVIDER: S-EPMC10032597 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature