Regulatory and coding sequences of TRNP1 co-evolve with brain size and cortical folding in mammals.

ABSTRACT: Brain size and cortical folding have increased and decreased recurrently during mammalian evolution. Identifying genetic elements whose sequence or functional properties co-evolve with these traits can provide unique information on evolutionary and developmental mechanisms. A good candidate for such a comparative approach is TRNP1, as it controls proliferation of neural progenitors in mice and ferrets. Here, we investigate the contribution of both regulatory and coding sequences of TRNP1 to brain size and cortical folding in over 30 mammals. We find that the rate of TRNP1 protein evolution (ω) significantly correlates with brain size, slightly less with cortical folding and much less with body size. This brain correlation is stronger than for >95% of random control pro

SUBMITTER: Kliesmete Z 

PROVIDER: S-EPMC10032658 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature