Pvr regulates cyst stem cell division in the Drosophila testis niche, and has functions distinct from Egfr.

ABSTRACT: Regulation of the rate of stem cell division is one of the key determinants of the abundance of differentiating progeny in stem cell-supported tissues, and mis-regulation can lead to tumorigenesis. The well-studied Drosophila testis niche is an excellent model system to study the regulation of stem cell division in vivo. This niche supports two stem cell populations-the germline stem cells (GSCs) and cyst stem cells (CySCs), which cluster around a group of cells called the hub. The differentiating cells of these two stem cell populations cooperate together to produce sperm. Signal transduction initiated by the epidermal growth factor receptor (Egfr) is a key regulatory pathway in the cyst lineage, and much of the study of this stem cell population has centered around understanding the comp

SUBMITTER: Mues N 

PROVIDER: S-EPMC10033353 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature