Hypocalcemia after parathyroidectomy in patients taking proton pump inhibitors.

ABSTRACT:

Purpose

Long-term use of proton pump inhibitors is associated with metabolic derangements, including hypocalcemia. Hypocalcemia is also a known complication of parathyroidectomy. We sought to determine the rate of hypocalcemia following parathyroidectomy in patients on proton pump inhibitors.

Materials and methods

The TriNetX Research Network was queried to identify patients with a history of primary hyperparathyroidism treated with parathyroidectomy between 2012 and 2022. The incidence of short-term (0-6 months following parathyroidectomy) and permanent (6-12 months following parathyroidectomy) postoperative hypocalcemia was compared between patients using proton pump inhibitors and those who were not.

Results

Of 34,595 total patients, 19.5 % (n = 6753) were taking p

SUBMITTER: Lorenz FJ 

PROVIDER: S-EPMC10033382 | biostudies-literature | 2023 Mar-Apr

REPOSITORIES: biostudies-literature