No short-term mortality from benzodiazepine use post-acute ischemic stroke after accounting for bias.

ABSTRACT:

Background and objectives

Older adults receive benzodiazepines for agitation, anxiety, and insomnia after acute ischemic stroke (AIS). No trials have been conducted to determine if benzodiazepine use affects poststroke mortality in the elderly.

Methods

We examined the association between initiating benzodiazepines within 1 week after AIS and 30-day mortality. We included patients ≥65 years, admitted for new nonsevere AIS (NIH-Stroke-Severity[NIHSS]≤ 20), 2014-2020, with no recorded benzodiazepine use in the previous 3 months and no contraindication for use. We linked a stroke registry to electronic health records, used inverse-probability weighting to address confounding, and estimated the risk difference (RD). A process of cloning, weighting, and censoring was used to avoid

SUBMITTER: Moura LMVR 

PROVIDER: S-EPMC10033385 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature