Antibiotic exposures and the development of pediatric autoimmune diseases: a register-based case-control study.

ABSTRACT:

Background

Antibiotics have been associated with several individual autoimmune diseases (ADs). This study aims to discover whether pre-diagnostic antibiotics are associated with the onset of ADs in general.

Methods

From a cohort of 11,407 children, 242 developed ADs (type 1 diabetes, autoimmune thyroiditis, juvenile idiopathic arthritis (JIA), or inflammatory bowel diseases) by a median age of 16 years. Antibiotic purchases from birth until the date of diagnosis (or respective date in the matched controls n = 708) were traced from national registers.

Results

Total number of antibiotic purchases was not related to the onset of ADs when studied as a group. Of specific diagnoses, JIA was associated with the total number of antibiotics throughout the childhood and with br

SUBMITTER: Raisanen LK 

PROVIDER: S-EPMC10033398 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature