Decreased expression of hypoxia-inducible factor 1α (HIF-1α) in cord blood monocytes under anoxia.

ABSTRACT:

Background

Infections are a major cause for morbidity and mortality in neonates; however, the underling mechanisms for increased infection susceptibility are incompletely understood. Hypoxia, which is present in inflamed tissues, has been identified as an important activation signal for innate immune cells in adults and is mainly mediated by hypoxia-inducible factor 1α (HIF-1α). Fetal tissue pO₂ physiologically is low but rises immediately after birth.

Methods

In this study, the effect of low oxygen partial pressure (pO₂) on HIF-1α expression and its targets phagocytosis, reactive oxygen species (ROS) production and vascular endothelial growth factor (VEGF) secretion was compared in vitro between immune cells from adult peripheral blood and cord blood u

SUBMITTER: Schlegel C 

PROVIDER: S-EPMC10033401 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature