Fetal endothelial colony-forming cell impairment after maternal kidney transplantation.

ABSTRACT:

Background

Successful pregnancies are nowadays possible after kidney transplantation but are associated with a higher incidence of maternal and fetal complications. Immunosuppressive therapy causes cardiovascular side effects but must be maintained during pregnancy. Little is known about the consequences of maternal kidney transplantation on offspring's endothelial health. Endothelial colony forming cells (ECFCs) represent a highly proliferative subtype of endothelial progenitor cells and are crucial for vascular homeostasis, repair and neovascularization. Therefore, we investigated whether maternal kidney transplantation affects fetal ECFCs' characteristics.

Methods

ECFCs were isolated from umbilical cord blood of uncomplicated and post-kidney-transplant pregnancies and ana

SUBMITTER: Meyer N 

PROVIDER: S-EPMC10033415 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature